Chronic cerebrovascular diseases: pathogenetic heterogeneity and therapeutic strategies
نویسندگان
چکیده
منابع مشابه
Peritoneal fibrosing syndrome: pathogenetic mechanism and current therapeutic strategies.
Peritoneal dialysis (PD) has been established as a main renal replacement therapy for approximately 20 years. However, long-term peritoneal exposure to high glucose and other unphysiologic contents in the PD solution may potentiate the development of peritoneal fibrosing syndrome (PFS) in PD patients. PFS is composed of a wide spectrum of peritoneal alterations, which has been observed in PD pa...
متن کاملActivated protein C based therapeutic strategies in chronic diseases.
Activated protein C (aPC) is a natural anticoagulant and a potent anti-inflammatory and cytoprotective agent. At the expense of increased bleeding risk aPC has been used - with some success - in sepsis. The design of cytoprotective-selective aPC variants circumvents this limitation of increased bleeding, reviving the interest in aPC as a therapeutic agent. Emerging studies suggest that aPC`s be...
متن کاملIdentifying Therapeutic Targets in Cerebrovascular Diseases Using Wholegenome Transcriptomics
Volume 1 • Issue 3 • 1000e104 Biochem Anal Biochem ISSN:2161-1009 Biochem, an open access journal DNA array technology may provide insight into the mechanisms underlying differences between old and young animals in rate and extent of brain repair and regeneration after stroke. Recently, by using custom macroarrays, we were able to show that expression of genes related to DNA damage, apoptosis a...
متن کاملPathogenetic and therapeutic implications of the histamine H4 receptor in inflammatory skin diseases and pruritus.
Chronic inflammatory skin diseases such as atopic dermatitis (AD) are clinically characterized by erythematous and pruritic skin lesions, immunologically mediated by an inflammatory infiltrate consisting of T-cells, antigen presenting cells (APC) and eosinophilic granulocytes. Histamine levels are increased in lesions of inflammatory skin diseases. It is likely that histamine also plays a patho...
متن کاملRefractory chronic lymphocytic leukemia – new therapeutic strategies
Treatment outcome of chronic lymphocytic leukemia (CLL) has considerably improved since the introduction of fludarabine (F) as part of the standard therapy. Nevertheless, refractoriness to fludarabine occurs in a significant number of patients and is associated with an unfavorable prognosis. Important risk factors are 17p deletion and/or mutation of TP53. For this subgroup the CD52 antibody ale...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Medical Council
سال: 2018
ISSN: 2079-701X
DOI: 10.21518/2079-701x-2018-18-50-55